A recent article published by PhD Ajoy Basak in Biomolecules delves into the current landscape of cholesterol-lowering treatments, focusing on both oral and non-oral medications targeting PCSK9 and other biomolecules. The review assesses the efficacy, mechanisms, and future prospects of these therapies in managing hypercholesterolemia and cardiovascular diseases.

The PCSK9 inhibitors market is poised for robust growth, driven by the rising prevalence of hypercholesterolemia, dyslipidemia, and cardiovascular diseases worldwide. Growing adoption of advanced lipid-lowering therapies among patients unable to achieve adequate LDL-C control with statins is further supporting market expansion. The recent approval of Merck’s LIPFENDRA and the emergence of next-generation oral PCSK9 inhibitor drugs, including, AstraZeneca’s AZD0780 and Aqur Biosciences’ AQR-008 is expected to broaden treatment options and improve adherence.

Merck (NYSE: MRK), known as MSD outside of the United States and Canada, today announced the U.S. Food and Drug Administration (FDA) has approved LIPFENDRA® (enlicitide) tablets 20 mg as an adjunct to diet and exercise to reduce low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia, including heterozygous familial hypercholesterolemia (HeFH).

LIB Therapeutics Inc. (LIB), a privately held biopharmaceutical company with a singular focus on helping high-risk patients achieve their cholesterol goals, today announced the U.S. Food and Drug Administration (FDA) has approved LEROCHOL™ (lerodalcibep-liga) injection for subcutaneous use as an adjunct to diet and exercise to reduce low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia, including heterozygous familial hypercholesterolemia (HeFH).

WESTLAKE VILLAGE, Calif. – Aqur Biosciences, Inc. (“Aqur” or the “Company”), a bioscience company dedicated to pioneering next-generation cardiovascular therapies, today announced its inclusion in DelveInsight’s 2025 report, “PCSK9 Inhibitors Market: Current Landscape and Market Forecast (2023–2034).”

We are pleased to announce the appointment of two distinguished experts to our Scientific Advisory Board: Professor Khaled Machaca, PhD, and Dr. George M. Tsoukas, MD, FRCPC.

Eli Lilly and Company (NYSE: LLY) and Verve Therapeutics, Inc. (Nasdaq: VERV), a Boston-based clinical-stage company developing genetic medicines for cardiovascular disease, today announced a definitive agreement for Lilly to acquire Verve.

Merck (NYSE: MRK), known as MSD outside of the United States and Canada, today announced positive topline results from the first two of three Phase 3 clinical trials evaluating the safety and efficacy of enlicitide decanoate, an investigational, oral proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor being evaluated for the treatment of adults with hyperlipidemia on lipid-lowering therapies, including at least a statin.

Aqur Biosciences, Inc. (“Aqur” or the “Company”), a bioscience company dedicated to pioneering next-generation cardiovascular therapies, is proud to announce the launch of its new brand identity — a reflection of the Company’s renewed strategic focus, innovative pipeline, and unwavering commitment to transforming patient care.

Verve Therapeutics has generated evidence its PCSK9 pivot could pay off. One year after dropping a base editing candidate over a safety signal, the biotech has shown its Eli Lilly-partnered successor can achieve similar cholesterol reductions without raising any red flags.

Positive results from the PURSUIT Phase IIb trial for AstraZeneca’s AZD0780 demonstrated a statistically significant low-density lipoprotein cholesterol (LDL-C) reduction when administered on top of standard-of-care statin therapy, as compared with placebo. AZD0780 is an investigational once-daily oral PCSK9 inhibitor for patients currently not reaching their LDL-C lowering goal despite standard-of-care lipid-lowering therapies such as statins.

The PCSK9 inhibitor market is projected to experience substantial growth due to its use in statin-intolerant patients, emerging strategies for PCSK9 inhibition, its potential applications across broader therapeutic areas, and its role in prophylactic treatment, which could help alleviate the burden of cardiovascular disease.